Quantitative Systems Pharmacolgy
Research Fellow Position Filled as of 3/30/2016
Quantitative systems pharmacology (QSP) is an emerging field that combines systems biology approaches with pharmacokinetic/pharmacodynamic (PK/PD) modeling principles. Mechanistic QSP models are characterized as multi-scale in nature and seek to describe the dynamic interplay among system components that give rise to emergent properties and regulate the interactions between drugs and biological systems. Enhanced Pharmacodynamics, LLC (ePD) is seeking a highly motivated individual to receive training in principles, methods, and applications of QSP modeling and to conduct research in advanced QSP modeling and simulation in drug development.
The postdoctoral fellow will be located in Buffalo, New York at the Center of Excellence in Bioinformatics and Life Sciences (http://www.buffalo.edu/bioinformatics.html). The primary objective is to construct QSP model(s) of fibrosis for evaluating novel therapeutic targets and guiding the development of antibody-based compounds designed to target and treat fibro-proliferative diseases. The postdoctoral fellow will be expected to interface with an inter-disciplinary team, including biologists, clinicians, and PK/PD modelers. There is also the potential for influencing the design and analysis of additional preclinical studies. Occasional domestic and international travel may be necessary for ePD-related business needs.
Develop a QSP model of fibrosis, including relevant signal transduction and cell-mediated processes, using literature and sponsor-generated data.
Conduct an extensive literature review using online databases and text mining tools to incorporate critical signaling and interacting systems.
Calibrate QSP model(s) to relevant data and perform sensitivity analyses and additional methods to optimize and qualify the final model(s).
Prepare research technical reports, manuscripts, and project support applications based on completed or anticipated research.
Coordinate collaborations with industrial scientists on this industrial-funded research project.
Aid in the design and preparation of experimental protocols and data analysis plans.
Interpret QSP, PK and PK-PD analyses, with appropriate input from other scientists.
Present research results to Sponsors, regulatory agencies, and at scientific symposia.
Travel for international and domestic meetings with Sponsors, regulatory agencies, and scientific symposia.
Effectively communicate modeling and simulation results in writing and presentations.
The maintenance of high ethical standards in research is a critical responsibility of the research community, and individuals involved in ePD research projects are expected to conduct research according to ethical standards understood in the scientific community.
Ph.D. degree in mathematics, engineering, pharmaceutical sciences, or other related biological or life sciences program with an emphasis on modeling and simulation.
Skills and Experience Requirements:
Expertise with quantitative systems pharmacology tools (e.g., MATLAB) is required.
As this is an advanced modeling appointment, applicant must possess strong fundamental skills in general mathematical and computational modeling, including experience with network-based analyses.
Applicant must have published at least two first-author papers in relevant journals demonstrating expertise in bioinformatics and/or systems analysis.
Experience with PK (e.g., WinNonlin® and/or other) and population PK modeling tools (e.g., NONMEM® and/or ADAPT II and/or NPEM and/or other) is desirable.
Applicant should be self-motivated, capable of conducting independent research, and possess strong problem solving capabilities and strong written and oral communication skills.
ePD provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, ePD complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.
ePD expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of ePD’s employees to perform their job duties may result in discipline up to and including discharge.
Applicants should submit (via email) a curriculum vitae, personal statement of research interests, and two letters of recommendation to the address below. This fellowship is for one year, but renewable for an additional year depending on research progress and funding.
Donald E. Mager, Pharm.D., Ph.D., FCP
President and CEO
Enhanced Pharmacodynamics, LLC
701 Ellicott Street
Buffalo, New York 14203
Phone: (888) 714-6624 ext. 2